Toxin Card
| Toxin ID: | arachnidatoxin-305 |
| Toxin Name: | δ-hexatoxin-Ar1a |
| Source Species: | Atrax robustus |
| Toxin Group: | Hexatoxin |
| Description: | Insecticidal and vertebrate-active toxin from the Sydney funnel-web spider Atrax robustus. A. robustus is one of the most dangerous spiders in the world and this toxin is responsible for the symptoms observed in humans following envenomation by this spider. δ-HXTX-Ar1a slows the inactivation of both vertebrate tetrodotoxin-sensitive voltage-gated sodium (Nav) channels and insect para-type sodium channels by binding to site 3 of the channel. It is not known whether δ-HXTX-Ar1a is specific for particular vertebrate Nav subtypes. An antivenom that neutralizes the effect of δ-HXTX-Ar1a was introduced in Australia in 1981 and there have been no recorded deaths due to bites from Atrax robustus or related funnel-web spiders since this time. |
| Discovered: | 1985 |
Source Spider Image
🧬 Annotated Sequence Map
Legend: Blue lines Disulfide bonds · Green triangles Pharmacophores · Yellow boxes PTMs
Physicochemical Properties
Avg Mass (Reduced)
4856.7
Avg Mass (Oxidised)
4848.64
pI
8.88
Extinction Coeff
14480.0
Current Taxonomy
| Kingdom | Phylum | Class | Order | Infra-order | Family | Genus | Species |
|---|---|---|---|---|---|---|---|
| Animalia | Arthropoda | Arachnida | Araneae | Mygalomorphae | Hexathelidae | Atrax | robustus |
Historical Taxonomy
| Genus | Species |
|---|---|
| Atrax | robustus |
| Euctimena | tibialis |
| Poikilomorpha | montana |
Mechanism of Action (MOA)
Neurotoxin
Molecular Targets & Potency
| Target | ED50 | IC50 | Kd | Comment |
|---|---|---|---|---|
| Vertebrate NaV channel, non-selective | - | - | - | - |
| Sodium channel, voltage-gated (para-type) (invertebrate) | - | - | - | - |
Phylogenetic Specificity
| Organism group | ED50 | LD50 | PD50 | Qualitative |
|---|---|---|---|---|
| Mus musculus | - | 33.0 | - | Native toxin, by subcutaneous injection. Calculated from 0.16 mg/kg. |
Original Deposition References
Sheumack D.D., Claassens R., Whiteley N.M., Howden M.E.H.
PubMed: 3972101 · FEBS Lett. 181:154-156(1985).
"Complete amino acid sequence of a new type of lethal neurotoxin from the venom of the funnel-web spider Atrax robustus."
Other Relevant Publications
Alewood D., Birinyi-Strachan L.C., Pallaghy P.K., Norton R.S., Nicholson G.M., Alewood P.F.
Biochemistry 42:12933-12940(2003). (PMID: 14596608)
"Synthesis and characterization of delta-atracotoxin-Ar1a, the lethal neurotoxin from venom of the Sydney funnel-web spider (Atrax robustus)."
Little M.J., Wilson H., Zappia C., Cestele S., Tyler M.I., Martin-Eauclaire M.-F., Gordon D., Nicholson G.M.
FEBS Lett. 439:246-252(1998). (PMID: 9845331)
"Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels."
Nicholson G.M., Walsh R., Little M.J., Tyler M.I.
Pflugers Arch. 436:117-126(1998). (PMID: 9560455)
"Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation."
Pallaghy P.K., Alewood D., Alewood P.F., Norton R.S.
FEBS Lett. 419:191-196(1997). (PMID: 9428632)
"Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus."
Temple M.D., Hinds M.G., Sheumack D.D., Howden M.E., Norton R.S.
Toxicon Mar;37(3):485-506(1999). (PMID: 10080353)
"1H NMR study of robustoxin, the lethal neurotoxin from the funnel web spider Atrax robustus."
Mylecharane EJ, Spence I., Sheumack D.D., Claassens R., Howden M.E.
Toxicon 27:481-492 (1989) (PMID: 2728033)
"Actions of robustoxin, a neurotoxic polypeptide from the venom of the male funnel-web spider (Atrax robustus), in anaesthetized monkeys"
Hartman L.J., Sutherland S.K.
Med. J. Aust. 141:796-799 (1984) (PMID: 6503783)
"Funnel-web spider (Atrax robustus) antivenom in the treatment of human envenomation"
Nicholson G.M., Little M.J., Tyler M., Narahashi T.
Toxicon 1996 34:1443-1453 (1996) (PMID: 9028001)
"Selective alteration of sodium channel gating by Australian funnel-web spider toxins"
Peptide Sequence Records
>as:δ-hexatoxin-Ar1a|sp:P01478 Vertebrate and insect toxin δ-hexatoxin-Ar1a from Sydney funnel-web spider Atrax robustus. CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_7 Translation of δ-hexatoxin-Ar1a_7 (XenFW86) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_2 Translation of δ-hexatoxin-Ar1a_2 (XenFW1) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_3 Translation of δ-hexatoxin-Ar1a_3 (XenFW2) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLTIVLGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_4 Translation of δ-hexatoxin-Ar1a_4 (XenFW3) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLTIVLGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_5 Translation of δ-hexatoxin-Ar1a_5 (XenFW4) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFVTIALGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_6 Translation of δ-hexatoxin-Ar1a_6 (XenFW80) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFVTIALGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_8 Translation of δ-hexatoxin-Ar1a_8 (XenFW87) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLRKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_9 Translation of δ-hexatoxin-Ar1a_9 (XenFW88) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFSLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_10 Translation of δ-hexatoxin-Ar1a_10 (XenFW89) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFVTIALGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_11 Translation of δ-hexatoxin-Ar1a_11 (XenFW90) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_12 Translation of δ-hexatoxin-Ar1a_12 (XenFW91) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_13 Translation of δ-hexatoxin-Ar1a_13 (XenFW92) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFVTIALGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_14 Translation of δ-hexatoxin-Ar1a_14 (XenFW94) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFVTIALGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_15 Translation of δ-hexatoxin-Ar1a_15 (XenFW95) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFVTIALGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_16 Translation of δ-hexatoxin-Ar1a_16 (XenFW96) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_17 Translation of δ-hexatoxin-Ar1a_17 (XenFW97) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_18 Translation of δ-hexatoxin-Ar1a_18 (XenFW99) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_19 Translation of δ-hexatoxin-Ar1a_19 (XenFW100) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFIQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_20 Translation of δ-hexatoxin-Ar1a_20 (XenFW101) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFVTIALGDFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_21 Translation of δ-hexatoxin-Ar1a_21 (XenFW102) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_22 Translation of δ-hexatoxin-Ar1a_22 (XenFW314) from the Sydney funnel-web spider Atrax robustus. MKITAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_23 Translation of δ-hexatoxin-Ar1a_23 (XenFW315) from the Sydney funnel-web spider Atrax robustus. MKITAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_24 Translation of δ-hexatoxin-Ar1a_24 (XenFW316) from the Sydney funnel-web spider Atrax robustus. MKITAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_25 Translation of δ-hexatoxin-Ar1a_25 (XenFW317) from the Sydney funnel-web spider Atrax robustus. MKITAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEADRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_26 Translation of δ-hexatoxin-Ar1a_26 (XenFW323) from the Sydney funnel-web spider Atrax robustus. MKITAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_27 Translation of δ-hexatoxin-Ar1a_27 (XenFW324) from the Sydney funnel-web spider Atrax robustus. MKITAALYVLFFLKIALGDFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_28 Translation of δ-hexatoxin-Ar1a_28 (XenFW326) from the Sydney funnel-web spider Atrax robustus. MKITAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_29 Translation of δ-hexatoxin-Ar1a_29 (XenFW327) from the Sydney funnel-web spider Atrax robustus. MKITAALYVLFFLKIALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
>as:δ-hexatoxin-Ar1a_30 Translation of δ-hexatoxin-Ar1a_30 (XenFW328) from the Sydney funnel-web spider Atrax robustus. MKVIAALYVLFFLKNALGDFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKRCAKKRNWCGKNEDCCCPMKCIYAWYNQQVSCQTTITGLFKKC
mRNA Sequence Records
>as:δ-hexatoxin-Ar1a_2 cDNA sequence (XenFW1) for δ-hexatoxin-Hv1a_2 from the Sydney funnel-web spider Atrax robustus. TTGATCTGCCTAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAAAAC
>as:δ-hexatoxin-Ar1a_3 cDNA sequence (XenFW2) for δ-hexatoxin-Hv1a_3 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGACAATTGTTCTTGGAGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCATATTAATGCGTTTTATGATATTATTTATCATATTAAATAAATGAGATAAAAATTGGAGGAGAAAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_4 cDNA sequence (XenFW3) for δ-hexatoxin-Hv1a_4 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGACAATTGTTCTTGGAGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCATATTAATGCGTTTTATGATATTATTTATCATATTAAATAAATGAGATAAAAATTGGAGGAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_5 cDNA sequence (XenFW4) for δ-hexatoxin-Hv1a_5 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTGTGACAATTGCTCTTGGCGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCATATTAATGCGTTTTACGATATTATTTATCATATTAAATAAATGAGATAAAAATTGGAGGAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_6 cDNA sequence (XenFW80) for δ-hexatoxin-Hv1a_6 from the Sydney funnel-web spider Atrax robustus. GATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTGTGACAATTGCTCTTGGCGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCATATTAATGCGTTTTACGATATTATTTATCATATTAAATAAATGAGATAAAAATTGGAACCAAAAAAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_7 cDNA sequence (XenFW86) for δ-hexatoxin-Hv1a_7 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCTAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCATGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_8 cDNA sequence (XenFW87) for δ-hexatoxin-Hv1a_8 from the Sydney funnel-web spider Atrax robustus. GATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAGGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_9 cDNA sequence (XenFW88) for δ-hexatoxin-Hv1a_9 from the Sydney funnel-web spider Atrax robustus. GATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTCTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_10 cDNA sequence (XenFW89) for δ-hexatoxin-Hv1a_10 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTGTGACAATTGCTCTTGGCGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCATATTAATGCGTTTTACGATATTATTTATCATATTAAATAAATGAGATAAAAATTGGAGGAGAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_11 cDNA sequence (XenFW90) for δ-hexatoxin-Hv1a_11 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCATGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACGCAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAGCTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_12 cDNA sequence (XenFW91) for δ-hexatoxin-Hv1a_12 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_13 cDNA sequence (XenFW92) for δ-hexatoxin-Hv1a_13 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTGTGACAATTGCTCTTGGCGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCATATTAATGCGTTTTACGATATTATTTATCATATTAAATAAATGAGATAAAAATTGGAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_14 cDNA sequence (XenFW94) for δ-hexatoxin-Hv1a_14 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTGTGACAATTGCTCTTGGCGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCATATTAATGCGTTTTACGATATTATTTATCATATTAAATAAATGAGATAAAAATTGGAGGAGAAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_15 cDNA sequence (XenFW95) for δ-hexatoxin-Hv1a_15 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTGTGACAATTGCTCTTGGCGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCATATTAATGCGTTTTATGATATTATTTATCATATTAAATAAATGAGATAAAAATTGGAGGAGAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_16 cDNA sequence (XenFW96) for δ-hexatoxin-Hv1a_16 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCATGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAA
>as:δ-hexatoxin-Ar1a_17 cDNA sequence (XenFW97) for δ-hexatoxin-Hv1a_17 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCAAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_18 cDNA sequence (XenFW99) for δ-hexatoxin-Hv1a_18 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCATGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAAAATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_19 cDNA sequence (XenFW100) for δ-hexatoxin-Hv1a_19 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCATCCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_20 cDNA sequence (XenFW101) for δ-hexatoxin-Hv1a_20 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTGTGACAATTGCTCTTGGCGACTTTTCTGAAGGAAATGAAAATGACCTGGTGGAGATCATGGAGAGCTTACCTGAGAAACTTTCTGAGGCCGATATTCCAGTTTTGAAGAAACTTGAAGCAATTGAAGATGCACTTTTGGTGAAGGATAGCTTGCCACATGCAGAAGAGGATAGAAGTGCACGTCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGACTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTAATTCTCGCTCTATTTTGTTACACAGTGATCTCCTTTATTTTCACCGAGTTAAATTAAACTGCGGTTTATGTACCATAATCANATNAANGNGTTTTACGATATTATCTATCATATTAAATAAATGAGATAAAATTGGAGGAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_21 cDNA sequence (XenFW102) for δ-hexatoxin-Hv1a_21 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCATGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_22 cDNA sequence (XenFW314) for δ-hexatoxin-Hv1a_22 from the Sydney funnel-web spider Atrax robustus. TCTACCATAATGAAAATAACAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_23 cDNA sequence (XenFW315) for δ-hexatoxin-Hv1a_23 from the Sydney funnel-web spider Atrax robustus. TCTACCATAATGAAAATAACAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAACAAAA
>as:δ-hexatoxin-Ar1a_24 cDNA sequence (XenFW316) for δ-hexatoxin-Hv1a_24 from the Sydney funnel-web spider Atrax robustus. CCTACCATAATGAAAATAACAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_25 cDNA sequence (XenFW317) for δ-hexatoxin-Hv1a_25 from the Sydney funnel-web spider Atrax robustus. CCTACCATAATGAAAATAACAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGCGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAAAAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_26 cDNA sequence (XenFW323) for δ-hexatoxin-Hv1a_26 from the Sydney funnel-web spider Atrax robustus. TCTACCATAATGAAAATAACAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCATGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_27 cDNA sequence (XenFW324) for δ-hexatoxin-Hv1a_27 from the Sydney funnel-web spider Atrax robustus. TCTACCATAATGAAAATAACAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATAAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCATGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCCCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_28 cDNA sequence (XenFW326) for δ-hexatoxin-Hv1a_28 from the Sydney funnel-web spider Atrax robustus. TCTACCATAATGAAAATAACAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_29 cDNA sequence (XenFW327) for δ-hexatoxin-Hv1a_29 from the Sydney funnel-web spider Atrax robustus. TCTACCATAATGAAAATAACAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAATTGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCCAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGGTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCTATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAAA
>as:δ-hexatoxin-Ar1a_30 cDNA sequence (XenFW328) for δ-hexatoxin-Hv1a_30 from the Sydney funnel-web spider Atrax robustus. TGATCTGCCATAATGAAGGTAATAGCAGCTTTGTACGTGCTTTTCTTTCTGAAAAATGCTCTTGGCGACTTTTCTGAAGGGAATGAAAATGACCTAGTGGAGAGCTTACCTGAGAAACTTTCTGAGGCAGATATTCCAGTTTTGAAGAAACTGGAAGCAATTGAAGATCCTCTTCTGGAGAAGGTTTTCTTGCAACATGCAGAGGAGGATAGAAATGCACGCCCAAAGAGATGTGCCAAGAAAAGAAATTGGTGTGGTAAGAATGAAGATTGCTGTTGTCCTATGAAATGTATCTACGCATGGTATAACCAGCAAGTTTCCTGTCAGACTACGATTACGGGACTCTTCAAAAAGTGTTGATTATCGATCCATTTTGTTACACAGCGACCTCCTTTATTTTCACCAAGATAAAATAAAACTTCGGTTTATGTACCATAATCATATTAAATAATTGAGATAAAAATTGGAGGAGAAATGTGTCGATGAACTCAGTTTATCTTTTCCAACGAAATTGTAATATCGCTATTTCTTCAAAATATTATTGAATAAAAATATGCAGCATTTCGAGAAAAAAAAAAAAAAAA
as:δ-hexatoxin-Ar1a|sp:P01478
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_7
MKVIAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_2
MKVIAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_3
MKVIAALYVLFFLTIVLG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_4
MKVIAALYVLFFLTIVLG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_5
MKVIAALYVLFFVTIALG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_6
MKVIAALYVLFFVTIALG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_8
MKVIAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLRKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_9
MKVIAALYVLFSLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_10
MKVIAALYVLFFVTIALG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_11
MKVIAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_12
MKVIAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_13
MKVIAALYVLFFVTIALG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_14
MKVIAALYVLFFVTIALG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_15
MKVIAALYVLFFVTIALG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_16
MKVIAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_17
MKVIAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_18
MKVIAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_19
MKVIAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFIQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_20
MKVIAALYVLFFVTIALG
DFSEGNENDLVEIMESLPEKLSEADIPVLKKLEAIEDALLVKDSLPHAEEDRSARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_21
MKVIAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_22
MKITAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_23
MKITAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_24
MKITAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_25
MKITAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEADRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_26
MKITAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_27
MKITAALYVLFFLKIALG
DFSEGNKNDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFMQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_28
MKITAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_29
MKITAALYVLFFLKIALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQGSCQTTITGLFKKC
as:δ-hexatoxin-Ar1a_30
MKVIAALYVLFFLKNALG
DFSEGNENDLVESLPEKLSEADIPVLKKLEAIEDPLLEKVFLQHAEEDRNARPKR
CAKKRNWCGKNEDCCCPMKCIYAWYNQQVSCQTTITGLFKKC
Signal
Propeptide
Mature Toxin
Excision
Chain
| Name / Synonym | Classification |
|---|---|
| δ-atracotoxin-Ar1a | Synonym |
| δ-ACTX-Ar1a | Synonym |
| Robustoxin | Synonym |
| RBX | Synonym |
| δ-hexatoxin-Ar1a | Recommended full name |
| δ-HXTX-Ar1a | Recommended abbreviation |
PDB: 1QDP
as:δ-hexatoxin-Ar1a|sp:P01478
UniProt: P01478
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Prediction
UniProt: P0DL88
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Prediction